In 2016, the United States Department of Justice Office for Victims of Crime (OVC) launched a national demonstration initiative to address the complex and interconnected needs of Family Justice Center clients who have experienced polyvictimization. OVC’s National Polyvictimization Demonstration Initiative challenged the lens through which Family Justice Centers and their staff viewed service delivery and assumptions held about client needs and resulted in the transformation of service delivery through the implementation of a more holistic polyvictimization framework. At the heart of the Initiative was the development of a validated Polyvictimization Assessment Tool (Assessment Tool) designed to assess lifetime victimization and trauma in clients. A Pathway to Justice, Healing and Hope – Addressing Polyvictimization in a Family Justice Center Setting – An Applied Book of Lessons Learned is a comprehensive account of this Initiative. The Applied Book: highlights the development, pilot testing, and implementation of the Assessment Tool; presents results, key findings, and lessons learned from the national evaluation; celebrates the power of multi-disciplinary collaboration; and provides and in-depth look into the successes, challenges, key findings, and lessons learned from each of the participating Family Justice Centers.